The Use of Short-term Antimicrobial Prophylaxis in Elective Surgery for Gastric Cancer.
10.5230/jkgca.2008.8.3.154
- Author:
Yoon SI
1
;
Hoon HUR
;
Sung Keun KIM
;
Kyong Hwa JUN
;
Hyung Min CHIN
;
Wook KIM
;
Cho Hyun PARK
;
Seung Man PARK
;
Keun Woo LIM
;
Seung Nam KIM
;
Hae Myung JEON
Author Information
1. Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea. hmjeon@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Antibiotic prophylaxis;
Surgical-site infection;
Gastric cancer;
Gastrectomy
- MeSH:
Anti-Bacterial Agents;
Antibiotic Prophylaxis;
Arm;
Emergencies;
Fever;
Gastrectomy;
Humans;
Neutrophils;
Stomach Neoplasms
- From:Journal of the Korean Gastric Cancer Association
2008;8(3):154-159
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Although most surgeons generally administer prophylactic antibiotics for more than three days, the optimal duration of antimicrobial prophylaxis in elective gastric surgery is still open to debate. The aim of this study was to determine if the duration of prophylactic antibiotic use can affect the recovery of patients after elective gastric surgery. MATERIALS AND METHODS: A total of 93 patients with gastric cancer were enrolled in this study, between January 2007 and December 2007. Patients were excluded if they had an infection at the time of surgery or they underwent an emergency operation. The first antibiotics were commonly given from just prior to the operation. The patients were divided into three groups according to the operation periods: those who received antibiotics only on the day of operation (arm A), those who received antibiotics for up to 3 days (arm B), and those who received antibiotics for more than 5 days postoperatively (arm C). The antibiotic that was used was second generation cephalosporin. RESULTS: The rate of surgical site infection was 12.9% (n=4) in arm A, 16.1% (n=5) in arm B and 19.4% (n=6) in arm C, respectively (P=0.788). No relationship was observed between the duration of prophylaxis and the rate of fever or the neutrophil counts during postoperative 7 days (P=0.119, P=0.855). CONCLUSION: The prophylactic effect of antibiotics on recovery, with the antibiotics being received only on the day of the operation, is as effective as receiving antibiotics for a longer duration after gastric cancer surgery.
