Preoperative Axillary Staging Using 18F-FDG PET/CT and Ultrasonography in Breast Cancer Patients.
10.4048/jbc.2009.12.3.163
- Author:
Yong Hun KIM
1
;
Jin Sun LEE
;
Chul Joo LEE
;
Je Ryong KIM
;
Eil Sung CHANG
Author Information
1. Department of Surgery, Research Institute for Medical Science, Chungnam National University School of Medicine, Daejeon, Korea. eschang@cnu.ac.kr
- Publication Type:Original Article
- Keywords:
Breast neoplasms;
Positron-emission tomography;
Ultrasonography
- MeSH:
Axilla;
Breast;
Breast Neoplasms;
Fluorodeoxyglucose F18;
Humans;
Lymph Nodes;
Neoplasm Metastasis;
Positron-Emission Tomography;
Recurrence;
Sensitivity and Specificity
- From:Journal of Breast Cancer
2009;12(3):163-169
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The axillary lymph node status is an important prognostic factor for recurrence and survival of patients who have primary breast cancer. This study determined the accuracy of ultrasonography and 18F-FDG positron emission tomography (PET)/computed tomography (CT) in preoperative staging in axilla in patients with breast cancer. METHODS: One hundred seventy-one patients with primary breast cancer were recruited from January 2007 to August 2008. All the patients underwent axillary ultrasonography and 18F-FDG PET/CT for the axillary staging before their operation. RESULTS: The overall sensitivity, specificity, and the positive and negative predictive values and the accuracy of axillary ultrasonography for making the diagnosis of axillary metastasis were 73.07%, 84.87%, 67.85%, 87.82%, and 81.28%, respectively. On a visual assessment of 18F-FDG PET/CT, the diagnostic accuracy was 85.38% with 69.23% sensitivity, 92.43% specificity, a positive predictive value of 80.00%, and a negative predictive value of 87.30%. By the combined use axillary ultrasonography and 18F-FDG PET/CT to the axilla, the sensitivity, specificity, the positive and negative predictive values and the diagnostic accuracy were 82.35%, 97.91%, 93.33%, 94.00%, and 93.84%, respectively. CONCLUSION: The combination of 18F-FDG PET/CT and ultrasonography improves preoperative axillary staging in breast cancer that are often not found if only one imaging modalities are applied.
