Paget's Disease of the Breast.
- Author:
Hyun Tae KIM
1
;
Jin Yong LEE
Author Information
1. Department of Surgery, Inje University College of Medicine, Paik Hospital, Busan, Korea.
- Publication Type:Original Article
- Keywords:
Paget's disease;
Breast cancer;
Axillary lymph node
- MeSH:
Breast;
Breast Neoplasms;
Carcinoma, Intraductal, Noninfiltrating;
Humans;
Mastectomy, Modified Radical;
Mastectomy, Radical;
Medical Records;
Nipples;
Paget's Disease, Mammary*;
Retrospective Studies;
Survival Rate
- From:Journal of the Korean Surgical Society
2001;61(1):40-45
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Paget's disease of the breast (PDB) occurs in approximately 1~3% of all primary breast carcinomas. This study aimed to determine the optimal surgical treatments for PDB in this study. METHODS: The medical records of 16 patients with PDB who had been treated between January 1986 and December 1998 were clinically reviewed retrospectively. RESULTS: 13 patients had nipple changes consistent with clinical Paget' disease (CPD) including 8 who had an associated breast mass, and 5 who had no associated mass. Of the 13 patients with CPD, 12 were treated with a modified radical mastectomy while 1 was treated with a radical mastectomy. Breast cancer (BC) was found in all of 13 patients (100%) with CPD. The BC was centrally located in 46% of patients including 38% in CPD associated with the mass and 60% in CPD not associated with the mass. Out of 8 CPD patients associated with the mass, 7 (88%) had invasive cancer, 1 (12%) had a ductal carcinoma in situ (DCIS), and 2 (25%) had pathologic axillary nodes (PAN). The 5 year survival rate was 87.5%. Of the 5 CPD patients not associated with the mass, 4 (80%) had an invasive cancer, 1 (20%) had a DCIS and none had PAN. Their 5 year survival rate is 100%. CONCLUSION: All the patients with CPD had an associated BC. BC is more frequently centrally located in the CPD not associated with the mass (60%) than those associated with the mass (38%). Contrarily, the BC in CPD that was not associated with the mass was located more peripherally (40%). Therefore, the treatment of patients with CPD must be individualized in order to avoid under or overtreatment.
