Hematologic Characteristics of Neonates Born to Pregnancy-Induced Hypertensive Mothers.
- Author:
Hye Sun YOON
1
;
Sung Jong PARK
;
EIIen A KIM
;
Ki Soo KIM
;
Soo Young PI
Author Information
1. Department of Pediatrics, Asan Medical Center, University of Ulsan, College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Pregnancy induced hypertension;
Neonatal neutopenia;
Neonatal thrombocytopenia
- MeSH:
Anti-Bacterial Agents;
Apgar Score;
Birth Weight;
Cesarean Section;
Chungcheongnam-do;
Female;
Gestational Age;
Humans;
Hypertension, Pregnancy-Induced;
Incidence;
Infant;
Infant, Newborn*;
Intensive Care, Neonatal;
Mothers*;
Neutropenia;
Neutrophils;
Pregnancy;
Retrospective Studies;
Sepsis;
Thrombocytopenia;
Thrombocytopenia, Neonatal Alloimmune
- From:Journal of the Korean Society of Neonatology
1998;5(2):158-166
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To determine clinical and hematological characteristics of infants born to pregnancy-induced hypertensive mothers and whether neutropenia in these infants is associated with an increased incidence of neonatal sepsis. METHODS: A retrospective study was conducted from June 1995 to June 1997 in 84 infants of pregnancy-induced hypertensive mothers who were admitted to the neonatal intensive care unit of Asan Medical Center. These infants were divided into 2 groups according to their absolute neutrophil counts(Group I: with neutropenia, Group II: without neutropenia) and their clinical, hematological and maternal characteristics were compared between these groups. RESULTS: 1) Infants in Group I were smaller, younger, and delivered more by cesarean section than in infants in Group II. 2) Neutropenia was observed in 77,7% of infants who were less than 30 weeks of gestational age and less than 1,500 g. Neutropenia and thrombocytopenia seem to be a transient phenomenon improving spontaneously approximately after 5.8 days and 8-10 days, respectively. 3) Sex, 1 min apgar score, type of delivery and initial use of antibiotics differ between these 2 groups. 4) There was no apparent increased risk for development of neonatal sepsis associated with neutropenia. CONCLUSION: Neutropenia and thrombocytopenia were observed in 40-50% infants born to pregnancy-induced hypertensive mothers. Such finding was more pronounced in infants whose gestational age was less than 32 weeks and birth weight was less than 1,500 g occuring at 70-80%. Neutropenia, per se, is not associated with increased incidence of sepsis but changes in hematological findings and clinical evidence is more important in predicting sepsis in these infants.
