Design of Korean Noninvasive Risk Evaluation Study for Sudden Cardiac Death from Infarction or Heart Failure: Heart failure study of K-REDEFINE registry.
10.18501/arrhythmia.2016.031
- Author:
Seung Jung PARK
1
;
Gyo Seung HWANG
;
Gi Byoung NAM
;
Hyung Wook PARK
;
Joong Wha CHUNG
;
Seung Yong SHIN
;
Sang Min KIM
;
Jun Hyung KIM
;
Young Soo LEE
;
Yae Min PARK
;
Jong Youn KIM
;
Dae Hyeok KIM
;
Dae kyeong KIM
;
June NAMGUNG
;
Dae Hee SHIN
;
Joon Hyouk CHOI
;
Hyoung Seob PARK
;
Jong Il CHOI
;
Jin Seok KIM
;
Tae Joon CHA
;
Sang Weon PARK
;
Jae Sun UHM
;
Nam Ho KIM
;
Minsoo AHN
;
Dong Gu SHIN
;
Nuri JANG
;
Meemo PARK
;
June Soo KIM
Author Information
1. Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. juneskim@skku.edu js58.kim@samsung.com
- Publication Type:Multicenter Study ; Original Article
- Keywords:
Sudden Cardiac Death;
Heart Failure;
Electrocardiography;
Ambulatory
- MeSH:
Arrhythmias, Cardiac;
Cause of Death;
Death, Sudden, Cardiac*;
Electrocardiography;
Heart Failure*;
Heart Rate;
Heart*;
Humans;
Incidence;
Infarction*;
Myocardial Infarction;
Prospective Studies;
Referral and Consultation;
Registries;
Risk Factors;
Stroke
- From:International Journal of Arrhythmia
2016;17(4):181-189
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND AND OBJECTIVES: Sudden cardiac death (SCD) is one of the most common causes of death in patients with heart failure (HF). However, there are no available data on SCD in previous Korean HF registries. Additionally, although widely used, the utility of left ventricular (LV) ejection fraction (EF) in risk stratification for SCD is limited. SUBJECTS AND METHODS: The Korean non-invasive Risk Evaluation study for sudden cardiac DEath From INfarction or heart failurE (KREDEFINE) is the first Korean prospective, nationwide multicenter registry, primarily focused on SCD. The registry consists of 2 groups of patients presenting with (1) acute HF or (2) acute myocardial infarction (MI) at 25 tertiary referral cardiovascular centers. Using the HF-group data of the K-REDEFINE registry, the incidence and risk factors of SCD in patients with HF will be assessed. In particular, the efficacy of Holter-based ECG variables, such as T-wave alternans (marker of repolarization heterogeneity) and heart rate turbulence/ variability (maker of autonomic function), in risk stratification for SCD will be evaluated. Other cardiovascular outcomes will also be analyzed, including atrioventricular arrhythmias, HF-related admission, stroke, and overall deaths. CONCLUSION AND PERSPECTIVE: The K-REDEFINE registry will pave the way for better management of patients with HF at high risk of SCD by elucidating the burden and risk factors of SCD and the clinical utility of various non-invasive ambulatory ECG-based parameters in risk stratification for SCD in this patient population.
