Incidence, Risk factors, and Clinical Outcomes of Contrast Induced Nephropathy After Percutaneous Coronary Intervention in Elderly Patients.
- Author:
Kwang Il KIM
1
;
Jangwhan BAE
;
Hyun Jae KANG
;
In Ho CHAE
;
Hyo Soo KIM
;
Dae Won SOHN
;
Cheo l Ho KIM
;
Byung Hee OH
;
Myoung Mook LEE
;
Young Bae PARK
;
Yun Shi k CHOI
Author Information
1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. cheolkim@plaza.snu.ac.kr
- Publication Type:Original Article
- Keywords:
Coronary disease;
Acute renal failure;
Angioplasty;
Contrast dye
- MeSH:
Acute Kidney Injury;
Aged*;
Angioplasty;
Coronary Disease;
Follow-Up Studies;
Hospitalization;
Humans;
Incidence*;
Multivariate Analysis;
Percutaneous Coronary Intervention*;
Renal Replacement Therapy;
Retrospective Studies;
Risk Factors*
- From:Journal of the Korean Geriatrics Society
2004;8(1):28-34
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Contrast induced nephropathy(CIN) has been known to be a risk factor of significant in-hospital and long-term adverse outcomes. In old aged patients undergoing percutaneous coronary intervention(PCI) in the modern era, the incidence and prognostic implications of nephropathy are unknown. METHODS: With a retrospective analysis of the clinical and angiographic data, we determined the incidence of, risk factors for, and prognostic implications of CIN(defined as an increase in serum creatinine[Cr] >0.5 mg/dL from baseline) after PCI. RESULTS: Of 360 patients, 16(4.4%) patients experienced CIN and 5(1.4%) patients required temporary renal replacement therapy (hemodialysis or hemofiltration). Patients with baseline Cr 1.4 mg/dL and diabetic patients had a significant risk of CIN. In multivariate analysis, CIN was significantly associated with baseline renal dysfunction and diabetes showed marginal significance in developing CIN. Twenty-five percent of patients with CINdied during the index hospitalization compared with only 1.2% of patients without CIN (p<0.001). In patients with CIN, events of CIN impair renal function at six-month follow up. CONCLUSIONS: In old aged patients who are undergoing PCI, diabetic patients with baseline renal impairment are at higher risk for CIN. Furthermore, CIN was highly correlated with death during the index hospitalization.
