Prognosis of Pregnancy-Associated Gastric Cancer: An Age-, Sex-, and Stage-Matched Case-Control Study.
- Author:
Min Jeong SONG
1
;
Young Soo PARK
;
Ho June SONG
;
Se Jeong PARK
;
Ji Yong AHN
;
Kee Don CHOI
;
Gin Hyug LEE
;
Hwoon Yong JUNG
;
Jeong Hwan YOOK
;
Byung Sik KIM
Author Information
- Publication Type:Original Article
- Keywords: Gastric neoplasms; Pregnancy; Prognosis; E-cadherins
- MeSH: Cadherins; Case-Control Studies*; Diagnosis; Estrogens; Fluorescence; Humans; In Situ Hybridization; Pregnancy; Prognosis*; Receptor, Epidermal Growth Factor; Receptor, Fibroblast Growth Factor, Type 2; Receptors, Progesterone; Stomach; Stomach Neoplasms*; Survival Rate; Tertiary Care Centers
- From:Gut and Liver 2016;10(5):731-738
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: Pregnancy-associated gastric cancer is a rare condition. This case-control study was performed to identify the clinicopathological features and prognostic factors of pregnancy-associated gastric cancer. METHODS: All consecutive patients who presented to our tertiary referral hospital with pregnancy-associated gastric cancer from 1991 to 2012 were identified. Two age-, sex-, and stage-matched controls for each case were also identified from the records. Clinicopathological, gynecological, and oncological outcomes were recorded. Immunohistochemical staining was performed for estrogen receptor, progesterone receptor, epidermal growth factor receptor, human epidermal growth factor receptor, and E-cadherin. Fluorescence in situ hybridization was performed for fibroblast growth factor receptor 2. RESULTS: The median overall survival rates of the pregnancy-associated gastric cancer and control groups were 7.0 months and 15.0 months, respectively (p=0.189). Poor prognostic factors included advanced stage and tumor location in the corpus or the entire stomach but not pregnancy status or loss of E-cadherin. Pregnancy-associated gastric cancer was associated with a longer time from diagnosis to treatment (21 days vs 7 days, p=0.021). The two groups did not differ in the expression of the receptors or E-cadherin. CONCLUSIONS: The dismal prognosis of pregnancy-associated gastric cancer may related to the tumor stage and location rather than to pregnancy itself.
