Antral or Pyloric Deformity Is a Risk Factor for the Development of Postendoscopic Submucosal Dissection Pyloric Strictures.
- Author:
Kyu Yeon HAHN
1
;
Jun Chul PARK
;
Hyun Jik LEE
;
Chan Hyuk PARK
;
Hyunsoo CHUNG
;
Sung Kwan SHIN
;
Sang Kil LEE
;
Yong Chan LEE
Author Information
- Publication Type:Original Article
- Keywords: Antral deformity; Pyloric deformity; Endoscopic submucosal dissection; Post-endoscopic submucosal dissection stricture
- MeSH: Congenital Abnormalities*; Constriction, Pathologic*; Early Intervention (Education); Hemorrhage; Humans; Multivariate Analysis; Retrospective Studies; Risk Factors*; Surgeons
- From:Gut and Liver 2016;10(5):757-763
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: Surgeons must be aware of risk factors for strictures before performing endoscopic submucosal dissection (ESD), to enable early interventions to prevent severe strictures. METHODS: This study was a single-center retrospective study. We reviewed the clinical data of patients who has undergone gastric ESD from January 2007 to December 2012. RESULTS: Among the 3,819 patients who had undergone gastric ESD, 11 patients (7.2%) developed pyloric strictures and received successful endoscopic balloon dilation. Significant differences were noted between the patients without and with post-ESD strictures for pretreatment of antral or pyloric deformities (46.4% vs 81.8%), the proportion of extension to the lumen circumference (>3/4, 9.4% vs 54.5%), the longitudinal extent of mucosal defects (27.9±10.1 mm vs 51.5±10.8 mm), and post-ESD bleeding (2.9% vs 27.3%). Multivariate analysis revealed that pretreatment antral or pyloric deformities (odds ratio [OR], 30.53; 95% confidence interval [CI], 1.476 to 631.565; p=0.027), larger longitudinal extent of mucosal defects (OR, 1.20; 95% CI, 1.074 to 1.340; p=0.001), and circumferential extension of 3/4 (OR, 13.69; 95% CI, 1.583 to 118.387; p=0.017) were independent risk factors for post-ESD stricture. CONCLUSIONS: Antral or pyloric deformities, sub-circumferential resection over more than 75% of the circumference and greater longitudinal extent of mucosal defects are independent risk factors for post-ESD stricture.
