Relationship between 25-Hydroxyvitamin D Levels and Liver Fibrosis as Assessed by Transient Elastography in Patients with Chronic Liver Disease.
- Author:
Bong Jin KO
1
;
Young Seok KIM
;
Sang Gyune KIM
;
Jung Hwan PARK
;
Sae Hwan LEE
;
Soung Won JEONG
;
Jae Young JANG
;
Hong Soo KIM
;
Boo Sung KIM
;
Sun Mi KIM
;
Young Don KIM
;
Gab Jin CHEON
;
Bo Ra LEE
Author Information
- Publication Type:Original Article
- Keywords: 25-Hydroxyvitamin D deficiency; Transient elastography; Liver stiffness
- MeSH: Diabetes Mellitus; Elasticity Imaging Techniques*; Hepatitis B, Chronic; Humans; Liver Cirrhosis*; Liver Diseases*; Liver*; Multivariate Analysis; Prognosis; Vitamin D; Vitamin D Deficiency
- From:Gut and Liver 2016;10(5):818-825
- CountryRepublic of Korea
- Language:English
- Abstract: BACKGROUND/AIMS: Deficiencies of 25-hydroxyvitamin D (25(OH)D) are prevalent in patients with chronic liver disease (CLD). Liver fibrosis is the main determinant of CLD prognosis. The present study was performed to evaluate the correlation between 25(OH)D levels and liver fibrosis as assessed by transient elastography (TE) in patients with compensated CLD. METHODS: Serum 25(OH)D levels and liver stiffness were determined in a total of 207 patients who were subjected to the following exclusion criteria: patients with decompensated CLD; patients who had malignancies; patients who were taking medications; and patients who were pregnant. RESULTS: The most common etiology was chronic hepatitis B (53.1%). Advanced liver fibrosis (defined by TE [≥9.5 kPa]) was present in 75 patients (36.2%). There was a significant correlation between 25(OH)D deficiency and liver stiffness. Based on the multivariate analysis, the following factors were independently associated with advanced liver fibrosis: 25(OH)D deficiency (odds ratio [OR], 3.46; p=0.004), diabetes mellitus (OR, 3.04; p=0.041), and fibrosis-4 index (OR, 2.01; p<0.001). CONCLUSIONS: Patients with compensated CLD exhibit a close correlation between vitamin D level and liver stiffness as assessed by TE. Vitamin D deficiency was independently associated with advanced liver fibrosis.
