Influence of Chronic Sinusitis and Nasal Polyp on the Lower Airway of Subjects Without Lower Airway Diseases.
10.4168/aair.2014.6.4.310
- Author:
Suh Young LEE
1
;
Soon Ho YOON
;
Woo Jung SONG
;
So Hee LEE
;
Hye Ryun KANG
;
Sun Sin KIM
;
Sang Heon CHO
Author Information
1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. shcho@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Bronchial hyperresponsiveness;
computed tomography;
nasal polyp;
pulmonary function test;
sinusitis
- MeSH:
Bronchial Provocation Tests;
Inflammation;
Lung;
Lung Diseases;
Nasal Polyps*;
Pathology;
Prospective Studies;
Respiratory Function Tests;
Respiratory System;
Retrospective Studies;
Sinusitis*
- From:Allergy, Asthma & Immunology Research
2014;6(4):310-315
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Upper and lower respiratory tract pathologies are believed to be interrelated; however, the impact of upper airway inflammation on lung function in subjects without lung disease has not been evaluated. This study investigated the association of CT finding suggesting chronic sinusitis and lung function in healthy subjects without lung disease. METHODS: This was a retrospective study of prospectively collected data from 284 subjects who underwent a pulmonary function test, bronchial provocation test, rhinoscopy, and osteomeatal unit computed tomography offered as a private health check-up option. RESULTS: CT findings showed that the sinusitis group had a significantly lower FEV1/FVC ratio than subjects without sinusitis finding (78.62% vs 84.19%, P=0.019). Among the sinusitis group, subjects classified by CT findings as the extensive disease group had a slightly lower FEV1/FVC than those of the limited disease group (76.6% vs 79.5%, P=0.014) and the associations were independent of the presence of airway hyperresponsiveness. The subjects with nasal polyp had also lower FEV1 and FEV1/FVC than subjects without nasal polyp (FEV1: 100.0% vs 103.6%, P=0.045, FEV1/FVC: 77.4% vs 80.0%, P=0.005). CONCLUSIONS: CT findings suggesting chronic sinusitis and nasal polyp were associated with subclinical lower airway flow limitation even in the absence of underlying lung disease.
