Reversible Symptomatic Myocarditis Induced by All-Trans Retinoic Acid Administration during Induction Treatment of Acute Promyelocytic Leukemia: Rare Cardiac Manifestation as a Retinoic Acid Syndrome.
- Author:
Seonghoon CHOI
1
;
Hyeong Su KIM
;
Chang Soo JUNG
;
Seong Woong JUNG
;
Yun Ja LEE
;
Jin Kyeong RHEU
;
Jung Rae JO
;
Nam Ho LEE
Author Information
- Publication Type:Case Report
- Keywords: Myocarditis; Retinoic acid syndrome; Acute promyelocytic leukemia
- MeSH: Induction Chemotherapy; Leukemia, Promyelocytic, Acute; Myocarditis; Pericardial Effusion; Tretinoin
- From:Journal of Cardiovascular Ultrasound 2011;19(2):95-98
- CountryRepublic of Korea
- Language:English
- Abstract: Treatment by All-trans retinoic acid (ATRA) followed by anthracycline-AraC chemotherapy has improved the outcome of acute promyelocytic leukemia. ATRA is usually well tolerated, but a few major side effects can be observed. Retinoic acid syndrome (RAS) often occurs during the induction chemotherapy of acute promyelocytic leukemia. A pericardial effusion is a common cardiac manifestation but myocarditis has been rarely documented. Here we reports a very rare case of fully recovered myocarditis as a result of RAS related to ATRA administration during induction treatment of acute promyelocytic leukemia which documented by echocardiographic evidence.
