A Case of Autoimmune Hemolytic Anemia Caused by Anti-e Antibody.
- Author:
Ye Jin KIM
1
;
Sang Woo KIM
;
Tae Hee HAN
Author Information
1. Department of Pediatrics, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Autoimmune hemolytic anemia;
Anti-e;
Immunoglobulin G
- MeSH:
Adult;
Anemia, Hemolytic;
Anemia, Hemolytic, Autoimmune;
Antibodies, Anti-Idiotypic;
Child;
Coombs Test;
Humans;
Immunoglobulin G;
Incidence;
Infant;
Prednisolone;
Sensitivity and Specificity
- From:Korean Journal of Blood Transfusion
2009;20(1):61-65
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The incidence of autoimmune hemolytic anemia in children is rarer than that in adults. It is estimated that the rate of autoimmune hemolytic anemia is around 2 persons per 10,000,000. We describe here a boy with warm autoimmune hemolytic anemia that was due to immunoglobulin G with an anti-e specificity. A 13-month-old boy with severe hemolytic anemia (hemoglobin: 6.0 g/dL) showed strong anti-IgG reactivity (4+) on the direct antiglobulin test. Antibody targeted against the e antigen was identified from both of his serum and the RBC eluate. In addition, he had e antigen on his RBCs. He was treated with prednisolone for 4 days and RBCs transfusions. After the second transfusion of RhD positive/e negative RBCs, his hemoglobin-level was increased to 10.3 g/dL. On his fifth hospital day, he was discharged with showing clinical improvement and improved values on his laboratory tests.
