Effect of tramadol on bispectral index during anesthesia with desflurane.
10.4097/kjae.2009.56.4.375
- Author:
Sang Hun KIM
1
;
Keum Young SO
;
Chong Dal CHUNG
;
Byung Sik YOO
;
Kyung Joon LIM
;
Tae Hun AN
;
Hyun Young LEE
;
Sang Jin LEE
;
Bo Heun YU
Author Information
1. Department of Anesthesiology and Pain Medicine, College of Medicine, Chosun University, Gwangju, Korea. kyso@chosun.ac.kr
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Bispectral index;
Desflurane;
Tramadol
- MeSH:
Adult;
Analgesia;
Anesthesia;
Anesthesia, General;
Arterial Pressure;
Hemodynamics;
Humans;
Isoflurane;
Propofol;
Surgical Procedures, Elective;
Tramadol
- From:Korean Journal of Anesthesiology
2009;56(4):375-380
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: This study is aimed to investigate the effect of tramadol on the bispectral index (BIS) during anesthesia with desflurane. METHODS: One hundred fifty adults, ASA class 1 and 2 patients, scheduled for general anesthesia for elective surgical procedures were included in this study. None of the patients were premedicated and anesthesia was induced with propofol 2 mg/kg and maintained with air-oxygen (FiO2 0.5) and desflurane, adjusted to keep the BIS between from 50 and 60. Forty minutes before completing surgery, the subjects were randomly allocated into 3 groups to receive saline (control group), tramadol 1.5 mg/kg (T1 group) or 3.0 mg/kg (T2 group) intravenously. Hemodynamics and BIS values were then recorded every 5 minutes until completion of the operation, during which time the concentrations of desflurane were not modified. RESULTS: The mean BIS values after tramadol administration weren't significantly different from the control group throughout the period of observation. No significant changes in the hemodynamics were noted, except systolic and diastolic arterial blood pressure in the T1 and T2 groups significantly increased in the first 5 minutes after the tramadol injection. CONCLUSIONS: The results indicate that the administration of tramadol while maintaining anesthesia with desflurane, adjusted to keep the BIS between 50 and 60, does not modified BIS values. So, we propose that tramadol can be safely administered as an immediate postoperative analgesia without concern about intra-operative awareness.
