Alterations of HLA Class I and II Antigen Expressions in Borderline, Invasive and Metastatic Ovarian Cancers.
- Author:
Yun Kyong KIM
1
;
Young Oak LEW
;
Sung Bae JEE
;
Gyu Moon KIM
;
Mi Young CHOI
;
Mi Ji KANG
;
Yong Seok LEE
;
Jin Woo KIM
Author Information
1. Molecular Genetic Laboratory, College of Medicine, The Catholic University of Korea, Seoul, Korea. jinwoo@cmc.cuk.ac.kr
- Publication Type:Original Article
- Keywords:
Ovary neoplasm;
HLA class I;
HLA class II
- MeSH:
Adenocarcinoma;
Adenocarcinoma, Mucinous;
Carcinogenesis;
Mucins;
Neoplasm Metastasis;
Ovarian Neoplasms*
- From:Journal of the Korean Cancer Association
2000;32(6):1031-1042
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The relationship between altered HLA expressions and ovarian carcinogenesis is not fully elucidated. MATERIALS AND METHODS: Histological evaluation comprised 20 serous adenocarcinoma, 5 borderline serous malignancy, 10 mucinous adenocarcinoma, 15 borderline mucinous malignancy. We used monoclonal antibodys to HLA class I beta2-microglobulin, class I B/C and class II heavy chain. RESULTS: There was no statistical difference in HLA expressions between borderline serous malignancy and normal ovarian tissue. In serous adenocarcinoma, beta2-microglobulin, B/C and class II heavy chain expressions were down-regulated. In metastatic cancer, B/C and class II ex pressions were also down-regulated. But the HLA expression of tumor or normal stromal tissue in primary tumor, were not down-regulated compared with the tissues in metastasis. In borderline mucinous malignancy, class II expressions were down-regulated. In mucinous adenocarcinoma, beta2-microglobulin, B/C and class II expressions were down-regulated. In metastatic ovarian cancer, B/C and class II expressions were down-regulated. But, in borderline malignancy, the result failed to reach statistical significance except class II of borderline mucinous malignancy. CONCLUSION: Loss of HLA class I and II molecules in invasive ovarian cancers raises the possibility that this could be a mechanism for tumor cells to have invasiveness.
