The Clinical Effect of 5% Imiquimod Cream in the Treatment of Verruca Plana.
- Author:
Un Ha LEE
1
;
Jung Chul CHOI
;
Duk Kyu CHUN
Author Information
1. Department of Dermatology, Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea. jj7074@hanmail.net
- Publication Type:Original Article
- Keywords:
Imiquimod;
Verruca plana
- MeSH:
Extremities;
Humans;
Neck;
Warts*
- From:Korean Journal of Dermatology
2005;43(1):1-5
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Despite numerous therapeutic options, the treatment of verruca plana remains unsatisfactory for both patients and physicians. Imiquimod, a novel topical immune response modifier, has been successfully used for the treatment of external anogenital warts. OBJECTIVE: The purpose of this study was to investigate the efficacy of imiquimod in treatment of verruca plana. METHOD: Fifteen patients with verruca plana were treated with 5% imiquimod cream that was self-applied 3 times a week and left in place overnight. Assessment for responses and side effects was performed every 2 weeks until clinical cure or up to 12 weeks. RESULTS: 10 of 15 (66.7%) patients achieved a excellent result (>75% improvement), and 11 (73%) patients achieved a good result (>50% improvement). With regard to the location of the lesions, 10 of 12 (83%) patients with lesions on the face and neck achieved a clear result (>95% improvement), but only 2 of 7 (28%) patients with lesions on the extremities achieved a clear result. Local inflammatory reactions were the most common adverse events, however, they were generally mild and transient. CONCLUSION: 5% imiquimod cream, applied by the patient, is an effective treatment modality for verruca plana.
