Differential Endothelial Function According to the Presence of Restenosis in Patients Having Undergone Percutaneous Transluminal Coronary Angioplasty.
10.4070/kcj.2001.31.11.1117
- Author:
Ki Rack PARK
1
;
Jang Ho BAE
Author Information
1. Division of Cardiology, College of Medicine, Konyang University, Daejeon, Korea. jhbae@kyuh.co.kr
- Publication Type:Original Article
- Keywords:
ndothelium, vascular;
Angioplasty, transluminal, percutaneous coronary;
Restenosis
- MeSH:
Angioplasty, Balloon, Coronary*;
Atherosclerosis;
Brachial Artery;
Chest Pain;
Coronary Artery Disease;
Fasting;
Follow-Up Studies;
Glucose;
Humans;
Risk Factors;
Ultrasonography
- From:Korean Circulation Journal
2001;31(11):1117-1122
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: e undertook this study to determine whether there is any difference in endothelial function according to the presence of restenosis in patients who had undergone percutaneous transluminal coronary angioplasty (PTCA), although it is well known that endothelial dysfunction is present in patients with coronary artery disease. SUBJECTS AND METHODS: he study population comprised 39 patients (mean age:1 years old, male:0 patients) who underwent PTCA a mean 12 months before follow-up coronary angiogram (CAG). We measured the flow-mediated brachial artery dilation (FMD) using high-resolution ultrasound 1 day before taking the follow-up CAG in an overnight fasting state. We also analyzed the risk factors of atherosclerosis, lipid and glucose levels, the presence of chest pain, and the types of drug taken by patients according to the presence of restenosis. RESULTS: MD was significantly lower in patients with restenosis (n=19) than without restenosis (7.5+/-3.7% vs 10.2+/-2.5%, p=0.013). However, there were no significant differences in other variables according to the presence of restenosis. CONCLUSION: ndothelial dysfunction was more pronounced in patients with restenosis than without restenosis following PTCA. However, we do not yet know whether the severity of endothelial dysfunction is a predictor for restenosis as the FMD was taken just prior to the follow-up coronary angiogram.
