Two Cases of Bortezomib-induced Drug Eruption Presenting as Multiple Plaques on the Trunk.
- Author:
Yun Seon CHOE
1
;
Eun Ji KIM
;
Jung Im NA
Author Information
1. Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea. vividna@gmail.com
- Publication Type:Case Report
- Keywords:
Bortezomib;
Drug eruption
- MeSH:
Drug Eruptions*;
Drug Therapy;
Edema;
Exanthema;
Humans;
Lower Extremity;
Mouth;
Multiple Myeloma;
Proteasome Inhibitors;
Vasculitis;
Bortezomib
- From:Korean Journal of Dermatology
2016;54(1):47-51
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Bortezomib (Velcade(R)) is proteasome inhibitor that is used as a first-line therapy for multiple myeloma. It can cause gastrointestinal, hematologic, and neuromuscular side effects, and a cutaneous reaction is one of its common adverse reactions. To date, several bortezomib-induced cutaneous adverse reactions have been reported, including folliculitis-like rash, pruriginous rash, purpuric rash, mouth swelling, stomatitis-mucositis, edema in the lower limbs, telogen effluvium, and vasculitis. In the Korean literature, only one case of vasculitis has been reported earlier. Two patients have presented with multiple plaques on the trunk at our clinic. The lesions developed several days after bortezomib chemotherapy, and disappeared spontaneously in about 1 week. Herein, we report bortezomib-induced drug eruption presenting as multiple plaques on the trunk with a review of the relevant literature.
