Three Cases of Allopurinol-induced DRESS Syndrome.
- Author:
Eun Kyoung JEON
1
;
Kyung Moon LEE
;
Yoo Bin KWON
;
Young Joon SEO
;
Jang Kyu PARK
;
Jeung Hoon LEE
Author Information
1. Department of Dermatology, Chungnam National University School of Medicine, Daejon, Korea. jhoon@cnu.ac.kr
- Publication Type:Case Report
- Keywords:
Allopurinol;
DRESS syndrome
- MeSH:
Allopurinol;
Drug Hypersensitivity Syndrome*;
Eosinophilia;
Exanthema;
Fever;
Gout;
Humans;
Lymph Nodes;
Lymphocytosis;
Skin;
Xanthine Oxidase
- From:Korean Journal of Dermatology
2007;45(7):714-719
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Allopurinol (4-hydroxypyrazolo-[3,4-d]pyrimidine) is an effective and widely used xanthine oxidase inhibitor administered in the treatment of hyperuricemic states such as gout. Allopurinol-induced DRESS (Drug rash with eosinophilia and systemic symptoms) syndrome is characterized by hematologic abnormalities, especially eosinophilia and mononucleosis-like atypical lymphocytosis, skin rash, fever, lymph node enlargement and single or multiple organ involvement, which starts within 8 weeks after the initiation of therapy. We report three cases of allopurinol-induced DRESS syndrome who developed erythematous skin eruption six weeks, nine weeks and seven weeks, respectively, after allopurinol therapy. The clinical, laboratory and histologic findings of these patients were compatible with allopurinol-induced DRESS syndrome.
