Radiation Recall Dermatitis Induced by Methotrexate.
- Author:
Dae Suk KIM
1
;
Hee Jung LEE
;
Yoonjin CHOI
;
Hye Jin CHUNG
;
Kee Yang CHUNG
Author Information
1. Department of Dermatology, Yonsei University College of Medicine, Seoul, Korea. kychung@yumc.yonsei.ac.kr
- Publication Type:Case Report
- Keywords:
Follicular lymphoma;
Methotrexate;
Radiation recall dermatitis
- MeSH:
Anti-Bacterial Agents;
Bandages;
Drug Therapy;
Humans;
Lymphoma, Follicular;
Methotrexate*;
Middle Aged;
Mitoxantrone;
Peripheral Blood Stem Cell Transplantation;
Pruritus;
Radiodermatitis*;
Radiotherapy;
Skin
- From:Korean Journal of Dermatology
2007;45(7):742-744
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Radiation recall dermatitis is the development of an inflammatory reaction in the previously irradiated area, precipitated by the administration of certain drugs. A 54-year-old man was diagnosed with follicular lymphoma, grade 3 and stage 3. Cancer recurred two years after complete remission obtained by chemotherapy and radiotherapy. Therefore, he was again treated with fludarabine and mitoxantrone for five cycles, then underwent an allogeneic peripheral blood stem cell transplantation (PBSCT). The patient started to receive methotrexate the day after PBSCT. On the day of the first methotrexate administration, the patient developed erythematous erosions with pruritus and severe pain in the previously irradiated area. The skin lesion resolved almost completely after dressing with topical antibiotics and wet dressing with 0.3% aluminium solution for 2 weeks. We report a case of radiation recall dermatitis in a patient with follicular lymphoma that occurred after receiving methotrexate.
