Apoptosis and Cell Proliferation in Gastric Adenoma and Adenocarcinoma.
10.5230/jkgca.2006.6.2.91
- Author:
Dong Soo LEE
1
;
Sang Bum KANG
;
Seung Woo LEE
;
Soon Woo NAM
;
Young Kyung YOO
;
Sok Won HAN
Author Information
1. Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Apoptosis;
Cell proliferation;
Gastric adenocarcionoma;
Gastric adenoma
- MeSH:
Adenocarcinoma*;
Adenoma*;
Apoptosis*;
Cell Death;
Cell Proliferation*;
Immunohistochemistry
- From:Journal of the Korean Gastric Cancer Association
2006;6(2):91-96
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Cancer is a genetic disease caused by alterations in key regulators of cell growth and cell turnover. We investigated apoptotic cell death and cell proliferation in gastric adenomas and adenocarcinomas. MATERIALS AND METHODS: The TdT-mediated dUTP-biotin nick end labelling (TUNEL) method and immunohistochemistry for Ki-67 were performed, using paraffin-embedded tissues of 41 gastric adenomas and 100 gastric adenocarcinomas. These results were compared with histopathologic parameters. RESULTS: The Ki-67 labelling index was higher in adenocarcinomas than in adenomas and the apoptotic index was higher in adenomas than in adenocarcinomas. There were no significant difference between the apoptotic index/Ki-67 labelling index and clinicopathological parameters. CONCLUSION: We propose that cell proliferation is more closely associated with gastric adenocarcinomas than apoptosis is, but that neither has any clinical significance as a prognostic factor in gastric adenocarcinomas.
