Continuous Renal Replacement Therapy (CRRT) in Intensive Care Unit (ICU) Patients with Acute Renal Failure.
- Author:
Eun Ah HWANG
1
;
Jeong Soo YOON
;
Mi Hyun JANG
;
Jung Eun KIM
;
Seong Sik KANG
;
Go CHOI
;
Seung Yeup HAN
;
Sung Bae PARK
;
Hyun Chul KIM
Author Information
1. Department of Internal Medicine, Keimyung University School of Medicine, Kidney Institutue, Korea. k780121@dsmc.or.kr
- Publication Type:Multicenter Study ; Original Article
- Keywords:
Kidney failure;
acute;
Renal replacement therapy;
Intensive care units
- MeSH:
Acute Kidney Injury;
APACHE;
Critical Illness;
Dialysis;
Humans;
Critical Care;
Intensive Care Units;
Linear Models;
Medical Records;
Platelet Count;
Renal Insufficiency;
Renal Replacement Therapy;
Respiration, Artificial;
Retrospective Studies;
Risk Factors;
Sepsis;
Serum Albumin
- From:Korean Journal of Nephrology
2009;28(6):559-569
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The mortality rate in critically ill patients with acute renal failure (ARF) remains unacceptably high, despite numerous advances in dialysis techniques and intensive care medicine. We evaluated clinical characteristics and prognostic factors in ICU patients with ARF requiring continuous renal replacement therapy (CRRT). METHODS: We retrospectively reviewed the medical records of all ICU patients who received CRRT at the Keimyung University Dongsan Hospital from September 2002 to October 2007. RESULTS: Total number of patients who required CRRT in ICU was 58. The mean age was 58.3+/-14.8 years. The treatment duration of CRRT was 63.5+/-40.7 hours. The mechanical ventilation rate was 82.8%, vasoactive drug 79.3%, sepsis 39.7%. APACHE II score was 25.2+/-7.9, SAPS II score 48.1+/-15.1, CCF score 9.3+/-3.6, the number of organ dysfunction 2.1+/-1.3. Overall mortality rate was 48%. When we compared sepsis group with non-sepsis group, the number of organ dysfunction and severity of illness were significantly higher in sepsis group than that of non-sepsis group. A mortality rate of sepsis group was significantly higher than non-sepsis group (82.6% vs 31.3%, p<0.001). In univariate analysis, significant risk factors for mortality were the number of organ dysfunction, severity of illness, MAP, platelet count, serum albumin level, and a type of hemofilter. Significances of all these factors were lost in multiple linear regression analysis. CONCLUSION: A large scaled, prospective randomized multi-center trials are needed to confirm the beneficial effect of CRRT in patient with ARF in ICU.
