Genetic Signatures of Asthma Exacerbation.
10.4168/aair.2017.9.3.191
- Author:
Heung Woo PARK
1
;
Kelan G TANTISIRA
Author Information
1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
- Publication Type:Review
- Keywords:
Asthma exacerbation;
genetics;
gene-environment interaction;
genome-wide association study;
pharmacogenetics
- MeSH:
Air Pollution;
Asthma*;
Compliance;
Continental Population Groups;
Demography;
Gene-Environment Interaction;
Genetics;
Genome-Wide Association Study;
Humans;
Pharmacogenetics;
Risk Factors;
Smoke;
Smoking
- From:Allergy, Asthma & Immunology Research
2017;9(3):191-199
- CountryRepublic of Korea
- Language:English
-
Abstract:
Asthma exacerbation (AE) usually denotes worsening of asthma symptoms that requires intense management to prevent further deterioration. AE has been reported to correlate with clinical and demographic factors, such as race, gender, and treatment compliance as well as environmental factors, such as viral infection, smoking, and air pollution. In addition, recent observations suggest that there are likely to be genetic factors specific to AE. Understanding genetic factors specific to AE is essential to develop therapy tailored for exacerbation-prone asthma. Here, we summarize the results of studies involving genetic risk factors for AE. To simplify and enhance understanding, we reviewed the studies according to the following categories: hypothesis-driven approaches, hypothesis-free approaches, gene-environment interactions, and pharmacogenetics.
