Short-Term Effect of High Dose of Vitamin C on Coronary Flow Velocity and Coronary Flow Reserve in Healthy Young Non-Smoker Men.
- Author:
Moo Rim PARK
1
;
Jin Won JEONG
;
An Saeng LEE
;
Kyung Ho YUN
;
Nam Jin YOO
;
Sung Hee SHIN
;
Eun Mi LEE
;
Seok Kyu OH
;
Nam Ho KIM
;
Ock Kyu PARK
Author Information
1. Department of Internal Medicine, Wonkwang University School of Medicine, The Institute of Medical Sciences, Iksan, Korea. jjwcar@wonkwang.ac.kr
- Publication Type:Original Article
- Keywords:
Coronary circulation;
Smokeless;
Ascorbic acid
- MeSH:
Ascorbic Acid*;
Coronary Circulation;
Echocardiography;
Humans;
Lobeline;
Male;
Vitamins*
- From:Journal of the Korean Society of Echocardiography
2004;12(2):78-82
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND AND OBJECTIVES: Vitamin C, water-soluble antioxidant, has been reported to restore coronary microcirculatory responsiveness and impaired coronary flow reserve in smokers. However, the effect of high dose of vitamin C on coronary circulation is unclear in nonsmokers. METHODS: We used transthoracic echocardiography to measure the coronary flow reserve, an integrated measure of coronary flow in 20 male healthy nonsmokers (26+/-3 years) before and after administration of the high dose of vitamin C. RESULTS: The coronary peak diastolic velocity was increased by 14.8% after administration of antioxidant vitamin C, whereas the coronary flow reserve did not changed. CONCLUSION: High dose of vitamin C acutely increases the coronary flow velocity without restoration of coronary flow reserve in male healthy nonsmokers.
