A Case of Acute Renal Failure Caused by Toxic Epidermal Necreolysis Combined with Rhabdomyolysis in A Patient with Idiopathic Hypoparathyroidism.
- Author:
Jong Hyun CHOI
1
;
Sang Min PARK
;
Kyung Cheon KIM
;
Ki Young CHOI
;
Sae Gwan PARK
;
Jong Won PARK
;
Young Ho SIN
;
Yong Hee LEE
Author Information
1. Department of Internal Medicine, Sunlin Hospital, HanDong University, Pohang, Korea. mindleholssi@hanmail.net
- Publication Type:Original Article
- Keywords:
Idiopathic hypoparathyroidism;
Acute Renal failure;
Rhabdomyolysis;
TEN
- MeSH:
Acute Kidney Injury*;
Biopsy;
Calcium;
Dermis;
Electrocardiography;
Erythrocytes;
Humans;
Hypoparathyroidism*;
Keratinocytes;
Lower Extremity;
Male;
Rare Diseases;
Renal Dialysis;
Rhabdomyolysis*;
Seizures;
Skin;
Spasm;
Stevens-Johnson Syndrome;
Stupor;
Thorax;
Vitamin D
- From:Korean Journal of Nephrology
2001;20(2):342-347
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Idiopathic hypoparathyroidism is extremely rare disease. We experienced an interesting case of idiopathic hypoparathyroidism associated with acute renal failure caused by toxic epidermal necrelysis combined with rhabdomyolysis. This 36-years-old male patient was suffered from bullous erythematous scalding skin lesion on lower extremity, back, and chest. After 10 days, he was admitted with the chief complaints of generalized seizure, carpopedal spasm, stuporous mentality. Skin biopsy showed edematous change with extravasated erythrocytes in upper dermis and several individually necrotic keratinocytes. On laboratory finding, marked decreased serum PTH level were demonstrated. Increased muscle uptake of technetium-99m MDP were noticed on bone scan. Prolonged Q-T interval on electrocardiogram was also noted. We could diagnose his disease as severe hypocalcemia(hypocalcemic crisis) developed associated with acute renal failure caused by toxic epidermal necrolysis combined with rhabdomyolysis in patient with idiopathic hypoparathyroidism. He was treated by hydration, urine alkalinization, 2 times of hemodialysis and supplementary calcium, vitamin D during the admission.
