Antineutrophil cytoplasmic antibody-negative pauci-immune glomerulonephritis with massive intestinal bleeding.
10.1016/j.krcp.2014.11.005
- Author:
Miyeon KIM
1
;
Young Uck KIM
;
Sun Jin BOO
;
So Mi KIM
;
Hyun Woo KIM
Author Information
1. Division of Nephrology, Department of Internal Medicine, Jeju National University School of Medicine, Jeju, Korea. andrewmanson@naver.com
- Publication Type:Case Report
- Keywords:
Gastrointestinal hemorrhage;
Glomerulonephritis;
Vasculitis
- MeSH:
Angiography;
Antibodies, Antineutrophil Cytoplasmic;
Antibodies, Antinuclear;
Arteries;
Biopsy;
Brain;
Cerebral Hemorrhage;
Complement System Proteins;
Consciousness;
Cyclophosphamide;
Cytoplasm*;
Edema;
Female;
Gastrointestinal Hemorrhage;
Glomerulonephritis*;
Hemorrhage*;
Humans;
Immunoglobulins;
Middle Aged;
Prednisolone;
Proteinuria;
Reference Values;
Vasculitis
- From:Kidney Research and Clinical Practice
2015;34(3):180-184
- CountryRepublic of Korea
- Language:English
-
Abstract:
A 61-year-old woman was admitted to hospital because of generalized edema and proteinuria. Her renal function deteriorated rapidly. Serum immunoglobulin and complement levels were within normal ranges. An autoantibody examination showed negative for antinuclear antibody and antineutrophil cytoplasmic antibody. Histologic examination of a renal biopsy specimen revealed that all of the glomeruli had severe crescent formations with no immune deposits. The patient was treated with steroid pulse therapy with cyclophosphamide followed by oral prednisolone. Fifteen days later, she experienced massive recurrent hematochezia. Angiography revealed an active contrast extravasation in a branch of the distal ileal artery. We selectively embolized with a permanent embolic agent. On the 45th hospital day, the patient suddenly lost consciousness. Brain computed tomography showed intracerebral hemorrhage. We report a case of antineutrophil cytoplasmic antibody-negative pauci-immune glomerulonephritis with massive intestinal bleeding and cerebral hemorrhage.
