Modification of pharmacokinetics of cefotaxime in uranyl nitrate-induced renal damage in black bengal goats.
- Author:
Biswa Priya DUTTA
1
;
Shiben Chandra DEBNATH
;
Tapan Kumar MANDAL
;
Animesh Kumar CHAKRABORTY
Author Information
1. Department of Pharmacology and Toxicology, Faculty of Veterinary & Animal Sciences, West Bengal University of Animal and Fishery Sciences, Mohanpur, Nadia, 741252, West Bengal, India. drtkm@rediffmail.com
- Publication Type:Original Article
- Keywords:
pharmacokinetics;
cefotaxime;
kidney damage;
goats
- MeSH:
Animals;
Anti-Bacterial Agents/blood/*pharmacokinetics;
Area Under Curve;
Cefotaxime/blood/*pharmacokinetics;
Female;
Goat Diseases/chemically induced/*metabolism;
Goats;
Half-Life;
Injections, Intramuscular;
Kidney Failure/chemically induced/*metabolism;
Uranyl Nitrate
- From:Journal of Veterinary Science
2004;5(1):1-3
- CountryRepublic of Korea
- Language:English
-
Abstract:
Pharmacokinetics of cefotaxime (50mg/kg, i.m.) were studied in both healthy and kidney damaged female black Bengal goats. Uranyl nitrate (0.75mg/kg) was administered intravenously, once daily for five consecutive days to induce kidney damage. The pharmacokinetic variables were calculated in both cases. Kidney damage caused several changes in the determined variables. The Cmax and Cmin of cefotaxime observed at 0.50 and 5 h in normal goats were 24.91+/-1.51 and 1.22+/-0.07 microgram/ml, respectively, while the same in kidney damaged goats at 1 and 72 h were 75.00+/-0.45 and 3.10+/-0.09 microgram/ml, respectively. Renal damage condition significantly increased t1/2,ka (0.48+/-0.01 h), t1/2,ke (20.03+/-0.16 h), AUC (2440.10+/-24.26 microgram. h/ml) and significantly decreased Vdarea (0.59+/-0.007L/kg), Vss (0.58+/-0.007 L/kg) and ClB (0.02+/-0.008 L/kg/h) values of cefotaxime compared to normal goats.
