Affecting Factors of Insulin Resistance in Obese Children and Adolescents.
- Author:
Duk Hee KIM
1
;
Ho Seon EUN
;
In Kyung CHOI
;
Ho Seung KIM
;
Bong Soo CHA
;
Dong Kee KIM
Author Information
1. Department of Pediatrics, College of Medicine, Yonsei University, Seoul, Korea. dhkim3@yumc.yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
Childhood obesity;
Adolescent obesity;
Insulin resistance;
Impaired glucose tolerance
- MeSH:
Adiponectin;
Adolescent*;
Blood Glucose;
C-Reactive Protein;
Cardiovascular Diseases;
Child*;
Diabetes Mellitus;
Female;
Glucose;
Glucose Tolerance Test;
Humans;
Insulin Resistance*;
Insulin*;
Leptin;
Linear Models;
Male;
Pediatric Obesity;
Plasma;
Risk Factors;
Triglycerides
- From:Korean Journal of Pediatrics
2005;48(10):1076-1081
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Insulin resistance is the most important risk factor linked to the development of impaired glucose tolerance (IGT), diabetes mellitus and cardiovascular diseases in childhood and adolescent obesity, The purpose of this study was to see whether insulin resistance of obese adolescent is higher than that of obese children. and to analyze gender difference and affecting factors of insulin resistance. METHODS: Of the 9, 837 school children from 5 to 16 tears old, 92 obese children and 187 adolescent, underwent a two-hour oral glucose tolerance test and plasma glucose, insulin, lipid profiles, leptin and high sensitive C-reactive protein (hs-CRP) were measure. RESULTS: Plasma insulin levels of female were higher compared to those of males during oral glucose tolerance test (P< 0.05). Four (4.3%) in obese children and twenty five (13.3%) in obese adolescents met the criteria of IGT. Female, leptin, adiponectin and triglyceride concentrations were strongly correlated with homeostatic model assessment insulin-resistance (HOMA-IR) by multiple linear regression analysis (P< 0.05). CONCLUSION: Obese adolescents might have higher insulin concentrations compared to obese children and obese girls higher insulin concentrations than obese boys. Obese boys and children with impaired glucose tolerance have higher insulin concentrations than those with normal glucose tolerance. HOMA-IR was significantly correlated with female, plasma leptin, adiponectin and triglyceride concentrations.
