A Case of Non-Hodgkin's Lymphoma Associated with Hepatocellular Carcinoma.
- Author:
Ju Byeung SUNG
;
Yong Cho KIM
;
Gyo Seon KWUN
;
Eun Jung JANG
;
Baek Yeol RYOO
;
Tae You KIM
;
Young Hyuck IM
;
Yoon Koo KANG
;
Chang Min KIM
;
Seung Sook LEE
;
Jhin Oh LEE
;
Tae Woong KANG
- Publication Type:Case Report
- Keywords:
Non - Hodgkin's lymphoma;
Hepatocellular carcinoma;
Multiple primary cancer
- MeSH:
Biopsy;
Carcinoma, Hepatocellular*;
Cyclophosphamide;
Doxorubicin;
Drug Therapy;
Early Detection of Cancer;
Ethiodized Oil;
Gelatin Sponge, Absorbable;
Hepatitis B Surface Antigens;
Hepatitis B virus;
Humans;
Incidence;
Korea;
Liver;
Liver Diseases;
Lymph Nodes;
Lymphoma, Large B-Cell, Diffuse;
Lymphoma, Non-Hodgkin*;
Middle Aged;
Mitomycin;
Neck;
Vincristine
- From:Korean Journal of Medicine
1997;53(4):556-560
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Multiple primary malignant neoplasms (MPMN) are defined by the presence of multiple primary cancers of multicentric origin and/or different tissues. The incidence of MPMN is less than 1% in Korea and recently seems to be increased due to early detection of cancer and prolonged survival of cancer patients. Previous investigations suggest that non-Hodgkin's lymphoma (NHL) may be associated with chronic liver disease and hepatocellular carcinoma (HCC). The pathogenesis of this association is thought to be due to chronic antigenic stimulation, the presence of HBsAg, and immunosuppressive therapy. We report a case of synchronous NHL and HCC in a 54-year-old man which is thought to be associated with hepatitis B virus infection. Pathological examination and immunohistochemical study of neck lymph node and liver mass biopsies showed diffuse large cell lymphoma and HCC, respectively. He was treated initially with EPOCH (etoposide, vincristine, doxorubicin, cyclophosphamide and prednisolone) chemotherapy for NHL and transarterial chemoembolization with doxorubicin, mitomycin-c, lipiodol, and gelfoam for HCC.
