Two Cases of Megaloblastic Anemia Induced by Vitamin B12 Deficiency in Children.
- Author:
Ji Yoon KIM
1
;
Byoung Mok KIM
;
Kun Soo LEE
Author Information
1. Department of Pediatrics, Kyungpook National University School of Medicine, Daegu, Korea. kslee@knu.ac.kr
- Publication Type:Case Report
- Keywords:
Megaloblastic anemia;
Vitamin B12 deficiency;
Chidren
- MeSH:
Anemia, Megaloblastic*;
Child*;
DNA;
Early Diagnosis;
Failure to Thrive;
Humans;
Megaloblasts*;
Vitamin B 12 Deficiency*;
Vitamin B 12*;
Vitamins*
- From:Korean Journal of Pediatric Hematology-Oncology
2004;11(1):97-101
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Megaloblastic anemia induced by Vitamin B12 deficiency is a disorder caused by impaired DNA synthesis. It has been previously thought to be rare in children, however, recent studies suggest that this condition is more common than previously recognized. Deficiency can lead to a wide spectrum of hematologic and neuropsychiatric disorders. Especially in children, it often presents with nonspecific manifestations, such as developmental delay, irritability, weakness, and failure to thrive. Early diagnosis and prompt treatment might resolve these complications, but permanent neurologic damage may have already occurred. We experienced two cases of Megaloblastic Anemia induced by Vitamin B12 deficiency and report them with a brief review of the literature.
