Gastrointestinal Stromal Tumors; Clinicopathological Features and Prognostic Factors.
- Author:
Do Won HA
1
;
Chan Heun PARK
Author Information
1. Department of Surgery, Hallym University College of Medicine, Seoul, Korea. hhh@hallym.or.kr
- Publication Type:Original Article
- Keywords:
GIST(gastrointestinal stromal tumor);
Clinical characteristics;
Prognostic factor
- MeSH:
Follow-Up Studies;
Gastrointestinal Stromal Tumors*;
Gastrointestinal Tract;
Humans;
Mitosis;
Mitotic Index;
Multivariate Analysis;
Prognosis;
Recurrence;
Retrospective Studies;
Stomach
- From:Journal of the Korean Surgical Society
2001;61(3):295-299
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Gastrointestinal stromal tumors (GIST) are a heterogenous group of mesenchymal neoplasms of the gastrointestinal tract. This study was performed to determine the clinical characteristics and prognostic factors of GIST. METHODS: We studied 24 cases of GIST collected over a 9 year period. This retrospective review analyzed the clinical presentation, pathologic examination, and long-term follow-up of patients with GIST. The clinicopathological features were evaluated to identify the predictors of survival. RESULTS: The most common clinical presentation was pain or discomfort (37.5%). GISTs were found to be typically present in older individuals and be most common in the stomach (41.7%). All patients underwent surgical resection with curative intent. The follow-up period ranged from 3 to 110 months. Recurrence occurred in 11 (45.8%) of 24 patients. According to multivariate analysis, survival was inversely correlated with size (P=0.032) and the number of mitoses (P=0.030). Patients younger than 50 had an independent value for prognostic prediction (P=0.058). CONCLUSION: Tumor size, mitotic index and patient's age can be used as prognostic factors for GIST according to the results of our study. But, better pathological and immunohistochemical methods are still required to improve GIST prognosis.
