Clinical Trial on the Hypotensive Effect of Carteolol.
10.4070/kcj.1987.17.4.789
- Author:
Dae Hyun YOO
;
Chang Rok SHIN
;
Myung Ju AHN
;
Jeong Hyun KIM
;
Heon Kil LIM
;
Bang Hun LEE
;
Chung Kyun LEE
- Publication Type:Clinical Trial ; Original Article
- MeSH:
Blood Pressure;
Carteolol*;
Dizziness;
Heart Rate;
Humans;
Hypertension
- From:Korean Circulation Journal
1987;17(4):789-794
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The clinical trial was carried out with carteolol in 30 patients with essential hypertension. The results were as follows : 1) Before medication and after 2,4,6 and 8 weeks of medications, the overall average systolic and diastolic blood pressure were 175+/-17.7/105+/-9.3, 144+/-8.9/92+/-6.9, 143+/-11.2/90+/-6.6, 141+/-8.4/88+/-6.9, and 142+/-9.0/88+/-7.1 mmHg. As a result, blood pressure significantly fell with carteolol treatment. 2) In 80+/- of all cases, marked or moderate degree of hypotnesive effect was observed within 2 weeks of treatment. 3) Before medication and after 2, 4, 6 and 8 weeks of medication, the overall average heart rates were 75+/-11.8, 73+/-9.0, 71+/-8.7, 71+/-8.2 and 71+/-8.6 beats/minute. There was no significant changes in heart rates before and after treatment. 4) Dizziness or fatigability were complained in 4 patients (13+/-) each while receiving carteolol. These side effects were mild in 3 patients, but one patient discontinued treatment due to dizziness. On the basis of these results, carteolol was evaluated to be promising hypotensive drug.
