Expression Pattern of EphB2 in Gastric Cancer.
10.5230/jkgca.2006.6.1.25
- Author:
Jae Hwi SONG
1
;
Chang Jae KIM
;
Young Gu CHO
;
Cho Hyun PARK
;
Suk Woo NAM
;
Nam Jin YOO
;
Jung Young LEE
;
Won Sang PARK
Author Information
1. Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea. wonsang@catholic.ac.kr
- Publication Type:Original Article
- Keywords:
Eph;
Tumor suppressor gene;
Tyrosine kinase receptor;
Immunohistochemistry;
Gastric cancer
- MeSH:
Carcinogenesis;
Epithelium;
Genes, Tumor Suppressor;
Humans;
Immunohistochemistry;
Lymph Nodes;
Mucous Membrane;
Neoplasm Metastasis;
Protein-Tyrosine Kinases;
Receptor, EphB2;
Stomach Neoplasms*;
Wnt Signaling Pathway
- From:Journal of the Korean Gastric Cancer Association
2006;6(1):25-30
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The EphB2 receptor, a member of the receptor tyrosine kinase family, is a target gene of the Wnt signaling pathway and may achieve a tumor suppressor function through regulation of cell growth and migration. Our aim was to determine whether an altered expression of EphB2 might be associated with gastric cancer development and, if so, to determine to which pathologic parameter it is linked. MATERIALS AND METHODS: For the construction of the gastric cancer tissue microarray, 83 paraffin-embedded tissues containing gastric cancer areas were cored 3 times and transferred to the recipient master block. The expression patterns of EphB2 were examined on tissue microarray slides by using immunohistochemistry and were compared using pathologic parameters, including histological type, depth of invasion, lymph node metastatsis, and peritoneal dissemination. RESULTS: The EphB2 protein was expressed in the normal gastric mucosal epithelium, especially in the bottom of the mucosa. We found loss of EphB2 expression in 30 (36.1%) of the 83 gastric cancer tissues. Statistically, loss of EphB2 expression was more common in gastric cancer with lymph-node metastasis. There was no significant correlation between EphB2 expression and depth of invasion, histologic type, or peritoneal dissemination. CONCLUSION: Our findings suggest that loss of EphB2 expression may represent a critical step in gastric carcinogenesis.
