Evaluation of the Performance of a Micromethod for Measuring Urinary Iodine by Using Six Sigma Quality Metrics.
10.3343/alm.2013.33.5.319
- Author:
Husniza HUSSAIN
1
;
Norhayati Mustafa KHALID
;
Rusidah SELAMAT
;
Wan Mohamud WAN NAZAIMOON
Author Information
1. Cardiovascular, Diabetes & Nutrition Research Centre, Institute for Medical Research, Kuala Lumpur, Malaysia. husniza@imr.gov.my
- Publication Type:Original Article ; Evaluation Studies ; Research Support, Non-U.S. Gov't
- Keywords:
Urinary iodine;
Method evaluation;
Sigma metrics;
Quality control;
Method acceptability
- MeSH:
Humans;
Iodine/*urine;
Laboratories/standards;
Quality Control;
Spectrophotometry/*standards;
Urinalysis/*standards
- From:Annals of Laboratory Medicine
2013;33(5):319-325
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: The urinary iodine micromethod (UIMM) is a modification of the conventional method and its performance needs evaluation. METHODS: UIMM performance was evaluated using the method validation and 2008 Iodine Deficiency Disorders survey data obtained from four urinary iodine (UI) laboratories. Method acceptability tests and Sigma quality metrics were determined using total allowable errors (TEas) set by two external quality assurance (EQA) providers. RESULTS: UIMM obeyed various method acceptability test criteria with some discrepancies at low concentrations. Method validation data calculated against the UI Quality Program (TUIQP) TEas showed that the Sigma metrics were at 2.75, 1.80, and 3.80 for 51+/-15.50 microg/L, 108+/-32.40 microg/L, and 149+/-38.60 microg/L UI, respectively. External quality control (EQC) data showed that the performance of the laboratories was within Sigma metrics of 0.85-1.12, 1.57-4.36, and 1.46-4.98 at 46.91+/-7.05 microg/L, 135.14+/-13.53 microg/L, and 238.58+/-17.90 microg/L, respectively. No laboratory showed a calculated total error (TEcalc)
