Clinical Significance of Tear Film Osmolarity for Non-Sjögren Dry Eye Diagnosis.
10.3341/jkos.2017.58.6.640
- Author:
Jun Myeong YUN
1
;
Hye Bin YIM
;
Hyun Seung KIM
;
Kyung Sun NA
Author Information
1. Department of Ophthalmology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea.
- Publication Type:Original Article
- Keywords:
Non-sjogren dry eye;
Schirmer's test;
Tear film osmolarity
- MeSH:
Cross-Sectional Studies;
Diagnosis*;
Dry Eye Syndromes;
Humans;
Osmolar Concentration*;
Tears*
- From:Journal of the Korean Ophthalmological Society
2017;58(6):640-645
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the diagnostic value of tear film osmolarity for non-Sjogren dry eye syndrome through measuring the correlation between tear osmolarity and several conventional dry eye parameters. METHODS: In this observational cross-sectional study, 274 patients (274 eyes) with non-Sjogren dry eye syndrome were examined using tear film osmolarity and the following conventional dry eye parameters: Schirmer's test, tear film break-up time, ocular surface disease index (OSDI), and corneal staining score. The correlations between tear film osmolarity and each conventional dry eye parameter were assessed using Spearman's correlation coefficients. RESULTS: The mean tear film osmolarity of the study population was 296.34 ± 21.08 mOsm/L. The tear film osmolarity was significantly negatively correlated with the Schirmer's test value (r = -0.431, p < 0.001) and tear break-up time (r = -0.131, p = 0.031), while it was significantly positively correlated with the OSDI scores (r = 0.191, p = 0.001) and corneal staining scores (r = 0.150, p = 0.013). CONCLUSIONS: Tear film instability was significantly correlated with other conventional dry eye parameters. However, additional studies are required to determine its feasibility as a stand-alone diagnostic tool.
