Long-term Results of Reduced-fluence Photodynamic Therapy Combined with Intravitreal Anti-Vascular Endothelial Growth Factor for Polypoidal Choroidal Vasculopathy.
10.3341/jkos.2017.58.6.646
- Author:
Ji Yun HAN
1
;
Seong Woo KIM
;
Jaeryung OH
Author Information
1. Department of Ophthalmology, Korea University College of Medicine, Seoul, Korea. ksw64723@korea.ac.kr
- Publication Type:Original Article
- Keywords:
Polypoidal choroidal vasculopathy;
Reduced fluence photodynamic therapy;
Vascular endothelial growth factor
- MeSH:
Choroid*;
Endothelial Growth Factors*;
Follow-Up Studies;
Humans;
Outcome Assessment (Health Care);
Photochemotherapy*;
Ranibizumab;
Retrospective Studies;
Vascular Endothelial Growth Factor A;
Visual Acuity
- From:Journal of the Korean Ophthalmological Society
2017;58(6):646-652
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the long-term effects of reduced-fluence photodynamic therapy (RF-PDT) combined with intravitreal anti-vascular endothelial growth factor (anti-VEGF) for polypoidal choroidal vasculopathy (PCV). METHODS: Twenty-two eyes of 21 patients with PCV that were followed up for more than 24 months after RF-PDT and anti-VEGF combination therapy were retrospectively reviewed. The patients received intravitreal anti-VEGF (bevacizumab 1.25 mg, ranibizumab 0.5 mg, or aflibercept 2.0 mg) within 7 days of PDT. Patients were retreated with either RF-PDT and anti-VEGF injection, or with only anti-VEGF injection, as indicated. The main outcome measures were best-corrected visual acuity (BCVA) and central foveal thickness (CFT), which were measured before and after combination therapy. RESULTS: During follow-up, the mean logMAR BCVA significantly improved from 0.75 at baseline to 0.54 at 12 months and 0.52 at 24 months (p=0.009 and p=0.032, respectively). The mean CFT significantly decreased from 409.8 µm at baseline to 234.1 µm at 12 months and 245.9 µm at 24 months (p<0.001 and p=0.001, respectively). In 20 eyes (90.9%), the BCVA remained stable or improved. CONCLUSIONS: The efficacy of this combination therapy for 24 months resulted in stabilized vision and anatomical improvement. RF-PDT combined with intravitreal anti-VEGF injection could be an effective treatment modality for patients with PCV.
