Association between Macrophage Migration Inhibitory Factor Gene Polymorphism and Rheumatoid Arthritis.
- Author:
Ju Kyoung SONG
1
;
Hyun Young SHIN
;
You Sun LEE
;
Jae Hee HWANG
;
Yang Sook KWON
;
Yeon Ju JEONG
;
Yun Jong LEE
;
Seong Wook KANG
Author Information
1. Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Korea. kangsw@cnuh.co.kr
- Publication Type:Original Article
- Keywords:
Rheumatoid arthritis;
Macrophage migration inhibitory factor;
Polymorphism
- MeSH:
Arthritis, Rheumatoid*;
Cytokines;
Genetic Predisposition to Disease;
Humans;
Macrophages*;
Polymorphism, Single Nucleotide
- From:The Journal of the Korean Rheumatism Association
2005;12(2):108-115
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: Rheumatoid arthritis (RA) is characterized by the interaction of multiple mediators, especially cytokines. Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine and has been shown to be involved in RA. This study explored the association of the MIF gene polymorphism with RA in Korean. METHODS: 114 patients with RA, and 114 age and gender matched healthy controls were studied. Patients and controls were genotyped for a single nucleotide polymorphism (SNP) in the 5'-flanking region at position -173 of the MIF gene. RESULTS: No significant differences in MIF gene polymorphism were observed in RA compared to healthy controls. No association with disease severity was detected for the MIF gene polymorphism. CONCLUSION: MIF -173 G/C polymorphism did not appear to be associated with genetic susceptibility and disease severity in Korean RA patients.
