Eukaryotic DNAJ/K Database: A Comprehensive Phylogenomic Analysis Platform for the DNAJ/K Family.

Author: Kyeongchae CHEONG ¹ ; Jaehyuk CHOI ; Jaeyoung CHOI ; Jongsun PARK ; Suwang JANG ; Yong Hwan LEE
Author Information

1. Fungal Bioinformatics Laboratory, Seoul National University, Seoul 151-921, Korea. yonglee@snu.ac.kr
Publication Type:Original Article
Keywords: database; HSP40 heat-shock proteins; HSP70 heat-shock proteins
MeSH: Eukaryota; Genome; HSP40 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; Humans; Molecular Chaperones; Proteins
From:Genomics & Informatics 2013;11(1):52-54
CountryRepublic of Korea
Language:English
Abstract: Proteins in DNAJ/K families are ubiquitous, from prokaryotes to eukaryotes, and function as molecular chaperones. For systematic phylogenomics of the DNAJ/K families, we developed the Eukaryotic DNAJ/K Database (EDD). A total of 12,908 DNAJs and 4,886 DNAKs were identified from 339 eukaryotic genomes in the EDD. Kingdom-wide comparison of DNAJ/K families provides new insights on the evolutionary relationship within these families. Empowered by 'class', 'cluster', and 'taxonomy' browsers and the 'favorite' function, the EDD provides a versatile platform for comparative genomic analyses of DNAJ/K families.