Primary Acinic Cell Carcinoma of the Breast: A Case Report with an Immunohistochemical and Ultrastructural Studies.
10.4048/jbc.2011.14.2.160
- Author:
Eun Deok CHANG
1
;
Eun Jung LEE
;
Ah Won LEE
;
Jeong Soo KIM
;
Chang Suk KANG
Author Information
1. Department of Pathology, The Catholic University of Korea College of Medicine, Seoul, Korea. changed@catholic.ac.kr
- Publication Type:Case Report
- Keywords:
Acinic cell carcinoma;
Breast neoplasms;
Electron microscopy;
Immunohistochemistry
- MeSH:
Acinar Cells;
Adult;
Breast;
Breast Neoplasms;
Carcinoma, Acinar Cell;
Cytoplasm;
Female;
Humans;
Immunohistochemistry;
Microscopy, Electron;
Muramidase;
Paneth Cells;
Salivary Glands
- From:Journal of Breast Cancer
2011;14(2):160-164
- CountryRepublic of Korea
- Language:English
-
Abstract:
Acinic cell carcinoma (ACC) of the breast is extremely rare and is characterized by widespread acinar cell-like differentiation. We report of a 39-year-old woman presented with a palpable breast mass with significant morphological, immunohistochemical and ultrastructural findings. Histologically, ACC showed a diffuse glandular infiltrative pattern, with small acinar or glandular structures mixed with solid nests. Neoplastic cells were monotonous proliferation of cells with a granular or clear cytoplasm, resembling acinar cells of the salivary glands or Paneth cells. Both glandular and solid tumor cell populations were strongly positive for lysozyme and alpha-1-antitrypsin.
