Nucleic Acid Recognition and Signaling by Toll-like Receptor 9: Compartment-dependent Regulation.
10.4167/jbv.2011.41.2.131
- Author:
Young Sang KOH
1
Author Information
1. Department of Microbiology & Immunology, Jeju National University School of Medicine, Jeju, Korea. yskoh7@jejunu.ac.kr
- Publication Type:Letter
- Keywords:
Toll-like receptor 9;
Membrane trafficking;
Adaptor complex AP-3
- MeSH:
Bacteria;
Cytokines;
DNA;
Interferon Type I;
Toll-Like Receptor 9;
Toll-Like Receptors
- From:Journal of Bacteriology and Virology
2011;41(2):131-132
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Toll-like receptor 9 binds to DNA from bacteria or viruses and activates a signaling pathway that leads to the induction of proinflammatory cytokines and type I interferon. Adaptor complex AP-3 was required for TLR9 trafficking and the production of type I interferon but not for proinflammatory cytokines. This suggests that TLR9 signaling is regulated by the subcellular localization of the receptor.
