A Case of Multiple Myeloma with Biclonal (IgG-K and IgA-K) M-proteins.
- Author:
Byeong Moon CHOI
1
;
Dal Sik KIM
;
Hye Soo LEE
;
Sam Im CHOI
Author Information
1. Department of Clinical Pathology, College of Medicine, Chonbuk National University, Chonju, Korea.
- Publication Type:Case Report
- Keywords:
Multiple myeloma;
M-protein;
Biclonal gammopathy;
Immunofixation
- MeSH:
Aged;
Electrophoresis;
gamma-Globulins;
Humans;
Immunoelectrophoresis;
Immunoglobulin A;
Immunoglobulin G;
Male;
Multiple Myeloma*;
Myeloma Proteins;
Plasma Cells
- From:Korean Journal of Clinical Pathology
1998;18(3):310-314
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Two M-protein peaks in serum protein electrophoresis are rarely present in patients with plasma cell discrasia. We describe a 72-year-old male patient with multiple myeloma secreting biclonal M-proteins, which were confirmed by immunofixation. Immunoelectrophoresis has some difficulties to dectect M components when a very small amount of M-protein develops an equivocally abnormal precipitation arc. In this case, serum protein electrophoresis revealed two M peaks, one in beta and the other in gamma globulin region. An immunoelectrophoresis revealed unequivocally abnormal precipitation arcs in IgA and K light chain regions, but the arc in IgG region was equivocal. We performed an immunofixation and confirmed biclonal gammopathy, IgA-K and IgG-K types. This result supports the view that immunofixation is an useful confirmatory test when immunoelectrophoresis results are equivocal.
