Potential Targeting of Siglecs, Mast Cell Inhibitory Receptors, in Interstitial Cystitis.
- Author:
Chang Shin PARK
1
;
Bruce S BOCHNER
Author Information
1. Department of Pharmacology, Inha University School of Medicine, Incheon, Korea. parkshin@inha.ac.kr
- Publication Type:Review
- Keywords:
Urinary bladder;
Interstitial cystitis;
Mast cells;
Sialic acid binding Ig-like lectin (Siglec)
- MeSH:
Cystitis, Interstitial;
Lectins;
Mast Cells;
Pelvic Pain;
Sialic Acid Binding Immunoglobulin-like Lectins;
Urinary Bladder;
Urinary Bladder Diseases
- From:International Neurourology Journal
2011;15(2):61-63
- CountryRepublic of Korea
- Language:English
-
Abstract:
Mast cell increases and activation are detected in the chronic inflammatory bladder disease interstitial cystitis (IC), and their proinflammatory mediators are felt to contribute to regional pelvic pain and inflammatory pathophysiology. The immunoreceptor tyrosine-based inhibition motif-containing sialic acid-binding immunoglobulin-like lectins (Siglecs) expressed in mast cells could be evaluated as in vivo signaling regulators capable of inhibiting IC-related mast cell activation.
