Tamsulosin Monotherapy versus Combination Therapy with Antibiotics or Anti-Inflammatory Agents in the Treatment of Chronic Pelvic Pain Syndrome.
- Author:
Tae Hyo KIM
1
;
Ki Soo LEE
;
Jeong Ho KIM
;
Joon Yeop JEE
;
Young Eun SEO
;
Dong Won CHOI
;
Yeul Geun SUNG
;
Geun Soo KONG
;
Dong Woo KIM
;
Won Yeol CHO
Author Information
1. Department of Urology, Dong-A University College of Medicine, Busan, Korea. urogate@dau.ac.kr
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Chronic Prostatitis with Chronic Pelvic Pain Syndrome;
Tamsulosin
- MeSH:
Academies and Institutes;
Anti-Bacterial Agents;
Anti-Inflammatory Agents;
Humans;
Pelvic Pain;
Prostate;
Prostatitis;
Quality of Life;
Sulfonamides
- From:International Neurourology Journal
2011;15(2):92-96
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: Chronic pelvic pain syndrome (CPPS) is treated by use of various protocols. We compared tamsulosin monotherapy with tamsulosin in combination with antibiotics or anti-inflammatory agents and evaluated the efficacy of these treatments in patients with CPPS. METHODS: Patients (n=107) who were younger than 55 years and diagnosed with CPPS were randomly assigned to treatment with tamsulosin at 0.2 mg (group A), tamsulosin at 0.2 mg plus anti-inflammatory drugs (group B) or tamsulosin at 0.2 mg plus antibiotics (group C) daily. We applied the National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI) and the International Prostate Symptom Score (IPSS) to evaluate 100 patients who were treated for 12 weeks (7 withdrew). Scores of the three groups were compared by analysis of variance and we also evaluated subscores, which included pain, voiding and quality of life (QoL). RESULTS: All three groups showed statistically significant decreases in NIH-CPSI score, IPSS and subscore scores (P<0.05). There were no statistically significant differences between the groups except for the QoL domain of the IPSS (group A vs. C; P<0.01). CONCLUSIONS: Tamsulosin monotherapy for 12 weeks was effective for treating patients with CPPS, compared with combination therapy with antibiotics or anti-inflammatory drugs.
