A Population Study of X-chromosomal STRs, DXS9898, DXS6809, DXS7424 and DXS10011 in Koreans.
- Author:
Myung Jin PARK
1
;
Hwan Young LEE
;
Chan Kwon JEONG
;
Seon Yeong LEE
;
Ji Eun YOO
;
Ukhee CHUNG
;
Jong Hoon CHOI
;
Chong Youl KIM
;
Kyoung Jin SHIN
Author Information
1. Department of Forensic Medicine, College of Medicine, Yonsei University, Korea. kjshin@yumc.yonsei.ac.kr
- Publication Type:Original Article
- Keywords:
STR;
X-chromosome;
null allele;
Korean
- MeSH:
Alleles;
Gene Frequency;
Humans;
Male;
Microsatellite Repeats;
Multiplex Polymerase Chain Reaction
- From:Korean Journal of Legal Medicine
2004;28(1):29-38
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A population study of the X-chromosomal short tandem repeat (STR) loci DXS9898, DXS6809, DXS7424 and DXS10011 was carried out by single multiplex PCR in a sample of 300 unrelated Korean individuals (150 males and 150 females). For accurate and reproducible STR typing, sequenced allelic ladders were constructed and GenoTyper macro was programmed. In this study, four types of the repre-sentative repeat sequence structure of DXS10011 were observed and the allele loss at DXS9898 was observed in 13 of 450 chromosomes (2.9%). The inter-population comparison of the allele frequencies at the 4 X-STRs showed significantly different distributions (p<0.01) for Koreans and Germans except DXS10011. All statistical parameters for forensic efficiency showed that the 4 X-chromosomal STRs are highly informative. Especially, DXS10011 is expected to be the most useful marker for forensic practice.
