Immunohistochemical Study on the Expression of p53 and bcl-2 Protein in Gallbladder Adenocarcinoma.
- Author:
Joon Hyuk CHOI
1
;
Young Ran SIM
;
Won Hee CHOI
Author Information
1. Department of Pathology, College of Medicine, Yeungnam University.
- Publication Type:Original Article
- Keywords:
Gallbladder;
Adenocarcinoma;
p53;
bc1-2;
Apoptosis
- MeSH:
Adenocarcinoma*;
Apoptosis;
Carcinogenesis;
Gallbladder*;
Genes, p53;
Lymph Nodes;
Neoplasm Metastasis
- From:Journal of the Korean Cancer Association
1998;30(4):660-667
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: This study was carried out to evaluate the expression of p53 and bcl-2 protein in the adenocarcinoma of gallbladder. MATERIALS AND METHODS: Thirty three cases of adenocarcinoma of gallbladder were immunohistochemically stained for p53 and bcl-2 protein. RESULTS: p53 protein was expressed in 51.5%(17/33) of adenocarcinoma. p53 protein expression was not significantly correlated with histologic grade of adenocarcinoma, depth of invasion, lymph node metastasis, distant metastasis and TNM stage, respectively(p>0.05). bcl-2 protein was expressed in 12.1%(4/33) of adenocarcinoma. bcl-2 protein expression was not significantly correlated with tumor size, histologic grade, depth of invasion, lymph node metastasis, distant metastasis and TNM stage, respectively(p>0.05). There is no correlation between expression of p53 and bcl-2 in gallbladder adenocarcioma(p > 0.05). CONCLUSION: This study suggest that p53 gene mutation plays an important role in carcinogenesis of gallbladder adenocarcinoma. The role of bcl-2 protein in gallbladder adenocarcinoma may be not significant.
