Complete Resolution of Posttransplant Lymphoproliferative Disorder (Diffuse Large B-cell Lymphoma) with Reduction of Immunosuppressive Therapy.
10.3349/ymj.2004.45.3.527
- Author:
Han Jak RYU
1
;
Jee Sook HAHN
;
Yu Seun KIM
;
Kiil PARK
;
Woo Ick YANG
;
Jong Doo LEE
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. medi@yumc.yonsei.ac.kr
- Publication Type:Case Report
- Keywords:
PTLD;
immunosuppression;
reduction;
resolution
- MeSH:
Adult;
Graft Rejection/*drug therapy;
Human;
Immunosuppressive Agents/*administration & dosage;
*Kidney Transplantation;
Korea;
Lymphoma, Large-Cell, Diffuse/*drug therapy/radiography/radionuclid imaging;
Male;
Remission Induction;
Tomography, Emission-Computed;
Tomography, X-Ray Computed
- From:Yonsei Medical Journal
2004;45(3):527-532
- CountryRepublic of Korea
- Language:English
-
Abstract:
Posttransplant lymphoproliferative disorder (PTLD) is a serious complication of organ transplantation. PTLD is the disorder arising from the combined effects of Epstein-Barr virus associated lymphoid proliferation with the disruption of the normal immune control by the cytotoxic T cells. The treatment for PTLD is one of the most controversial topics in solid organ transplantation. It is well known that the initial management of PTLD is a reduction of immunosuppression. Early diagnosis and the early reduction in immunosuppression are essential even for monomorphic lymphoma. We report here on a case of the complete resolution of PTLD (diffuse large B cell lymphoma) which occurred after a drastic reduction of immunosuppression in a renal transplant recipient.
