A Female Case of Kleine-Levin Syndrome Treated with Amantadine.
- Author:
Joon Ho AHN
1
;
Oh Su HAN
;
Je Chun YU
;
Chang Yoon KIM
Author Information
1. Department of Psychiatry, Ulsan University Hospital, College of Medicine, University of Ulsan, Ulsan, Korea.
- Publication Type:Case Report
- Keywords:
Kleine-Levin syndrome;
Recurrent hypersomnia;
Amantadine
- MeSH:
Adolescent;
Amantadine*;
Amnesia;
Depersonalization;
Disorders of Excessive Somnolence;
Female*;
Humans;
Hyperphagia;
Kleine-Levin Syndrome*;
Male
- From:Journal of Korean Neuropsychiatric Association
2002;41(4):725-732
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Kleine-Levin syndrome is a rare disorder which usually affects adolescent males and is characterized by periodic hypersomnia, hyperphagia and abnormal behavior. This is an unexplained clinical syndrome for which several etiologies have been entertained with no standard treatment is yet available. A 18-year old woman began suffering from recurrent hypersomnia, hyperphagia, and behavioral disturbances such as irritability, derealization, and amnesia. She was normal between the episodes and diagnosed as Kleine-Levin syndrome. In the course of about two years she had 11 episodes and the mean interval between the episodes was 52.8+/-16.7 days. After application of amantadine, there were two mild episodes and then she had no episodes for more than 6 months. This case suggests the possible role of amantadine in the treatment of Kleine-Levin syndrome.
