Serum biomarkers for predicting pregnancy outcome in women undergoing IVF: human chorionic gonadotropin, progesterone, and inhibin A level at 11 days post-ET.
10.5653/cerm.2012.39.1.28
- Author:
Jee Hyun KIM
1
;
Mi Sun SHIN
;
Gwang YI
;
Byung Chul JEE
;
Jung Ryeol LEE
;
Chang Suk SUH
;
Seok Hyun KIM
Author Information
1. Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Korea. blasto@snubh.org
- Publication Type:Original Article ; In Vitro
- Keywords:
Chorionic gonadotropin;
Progesterone;
Inhibins;
In vitro fertilization;
Embryo transfer;
Outcomes, pregnancy
- MeSH:
Biomarkers;
Chorionic Gonadotropin;
Embryo Transfer;
Enzyme-Linked Immunosorbent Assay;
Female;
Fertilization in Vitro;
Humans;
Inhibins;
Pregnancy;
Pregnancy Outcome;
Progesterone
- From:Clinical and Experimental Reproductive Medicine
2012;39(1):28-32
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: This study was performed to assess the prognostic value of serum hCG, progesterone, and inhibin A levels measured at 11 days post-ET for predicting pregnancy outcome in women participating in IVF. METHODS: Between May 2005 and April 2008, sera were obtained from 70 infertile women who underwent IVF-ET at 11 days post-ET and stored. HCG, progesterone, and inhibin A levels were measured by commercial enzyme-linked immunosorbent assay kits. The predictive accuracy of hCG, progesterone, and inhibin A levels for establishment of intrauterine pregnancy and ongoing pregnancy was calculated by receiver-operating characteristic curve analysis. RESULTS: For the prediction of intrauterine and ongoing pregnancy, serum hCG was better than progesterone and inhibin A. The predictive performance of progesterone and inhibin A was similar. The serum progesterone and inhibin A levels were significantly correlated each other (r=0.915, p=0.010). CONCLUSION: A single measurement of the serum hCG level is sufficient to predict pregnancy outcome in IVF-ET patients.
