A Clinical Trial on Antihypertensive Effect of Tripamide(Normonal(R)).
10.4070/kcj.1983.13.2.417
- Author:
Myung Bae PARK
;
Tae Won JUNG
;
Sung Pyo SON
;
Joong Gil LEE
;
Yung Woo SHIN
;
Young Kee SHIN
- Publication Type:Clinical Trial ; Original Article
- MeSH:
Blood Glucose;
Blood Pressure;
Cholesterol;
Creatinine;
Diuretics;
Fasting;
Hypertension;
Uric Acid
- From:Korean Circulation Journal
1983;13(2):417-422
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Antihypertensive effect and side effect of Tripamide(Normonal(R)) was studied in 22 cases of essential hypertension using 15mg once daily regimen for average period of 9 weeks. 1) Antihypertensive effect Average reduction of 25mmHg in systolic and 19mmHg in systolic and 19 mmHg in diastolic pressure was observed and reduction rate was 15.7% and 17.6% respectively. The overall effect rate was 86%. The blood pressure lowered significantly in 1 week of treatment both in systolic and diastolic pressure and the extent of fall in systolic pressure approached near the level of maximum reduction in 2 weeks of administration and that of diastolic after 5 weeks of treatment. 2) Laboratory tests and side effect There was no significant changes in individual and mean value of Na, K, Cl, BUN, creatinine, uric acid, fasting blood sugar, cholesterol, GOT, GPT studied before and after treatment except one case showing elevation of uric acid. No significant side effect was observed during trial except of 2 cases of transient diuretic effect.
