The Association of Exposure to Organic Solvents with Liver Function.
- Author:
Chi Young ANN
1
;
Kyung Jong LEE
;
Jae Bum PARK
;
Jae Yeon JANG
;
Moon Jong KIM
Author Information
1. Department of Medical Sciences, The Graduate School of Ajou University, Korea. leekj@madang.ajou.ac.kr
- Publication Type:Original Article
- Keywords:
Organic solvent;
Liver function test;
Cumulative exposure (CE)
- MeSH:
Alanine Transaminase;
Alcohol Drinking;
Bilirubin;
Environmental Monitoring;
Hepatitis B Surface Antigens;
Humans;
Liver Function Tests;
Liver*;
Logistic Models;
Male;
Odds Ratio;
Paint;
Paintings;
Smoke;
Smoking;
Solvents*
- From:Korean Journal of Occupational and Environmental Medicine
2001;13(1):64-74
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: This study was conducted to evaluate the association of cumulative exposure to organic solvent with liver function. METHODS: We conducted a cross sectional study. 461 male workers who perform painting job at a shipyard and use organic solvents routinely and 125 workers of the same shipyard who never have been exposed to organic solvents were studied. All subjects who were confirmed not having HBsAg surveyed their age, BMI(body mass index), alcohol drinking and smoking history, and examined liver function test (SGOT, SGPT, gamma-GTP, Total protein, albumin, total bilirubin, direct bilirubin). The amount of cumulative exposure (CE) to mixed organic solvents were measured by biological monitoring method using their metabolites in urine. RESULTS: The CE was observed as a significant variable with logistic regression analysis on abnormality of SGOT(>35IU/L), SGPT(>40IU/L) and gamma-GTP(>63IU/L), their odds ratio were 1.10 (95 %CI, 1.02-1.20), 1.10 (95 %CI, 1.01-1.19), and 1.10 (95 %CI, 1.01-1.19) each. CONCLUSIONS: Therefore we suggest that the cumulative exposure to mixed organic solvents might be a significant variable on abnormal liver function indices (SGOT, SGPT,gamma-GTP) in male shipyard workers
