A Case of Subcutaneous Panniculitic T-cell Lymphoma.
- Author:
Jae Hong PARK
1
;
Jee Ook KIM
;
Jun Hyung PARK
;
Young Wook RYOO
;
Byung Chun KIM
;
Kyu Suk LEE
Author Information
1. Department of Dermatology, Keimyung University, School of Medicine Taegu, Korea. atopypark@freechal.com
- Publication Type:Case Report
- Keywords:
Subcutaneous panniculitic T-cell lymphoma;
Hemophagocytic syndrome
- MeSH:
Abdomen;
Adult;
Biopsy;
Chills;
Diagnosis;
Extremities;
Fat Necrosis;
Female;
Fever;
Humans;
Lymphatic Diseases;
Lymphocytes;
Lymphohistiocytosis, Hemophagocytic;
Lymphoma, T-Cell*;
Lymphoma, T-Cell, Peripheral;
Panniculitis;
Skin;
T-Lymphocytes*
- From:Korean Journal of Dermatology
2001;39(6):703-706
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Subcutaneous panniculitic T-cell lymphoma(SPTCL) is a rare subtype of peripheral T-cell lymphoma that clinically and histologically mimics benign panniculitis. It represents subcutaneous nodules predominatly on extremities and trunk and hemophagocytic syndrome almost leading to death. A 29-year-old women presented with multiple tender subcutaneous nodules on lower abdomen and extremities for 6 months often with fevers and chills. There was no hepatosplenomegaly or lymphadenopathy. Skin biopsy specimen showed dense diffuse infiltration of atypical lymphocytes in the subcutis, with extensive fat necrosis and karyorrhexis. The immunophenotypic studies showed a cytoxic T-lymphocyte profile, i.e., LCA+, UCHL+, CD8+, CD20-, CD30-, and CD56-. In immunohistochemical studies for the Ebstein-Barr virus resulted in a negative finding. On the basis of the clinical and histological finding, we established the diagnosis of SPTCL.
